vanA-mediated high-level glycopeptide resistance inEnterococcus faeciumfrom animal husbandry
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چکیده
منابع مشابه
Moderate-level resistance to glycopeptide LY333328 mediated by genes of the vanA and vanB clusters in enterococci.
Three of five natural plasmids carrying a wild-type vanA gene cluster did not confer LY333328 glycopeptide resistance on Enterococcus faecalis JH2-2 (MIC = 2 microg/ml). The two remaining plasmids conferred resistance to the drug (MIC, 8 microg/ml). The vanB gene cluster did not confer resistance to LY333328, since this antibiotic was not an inducer. Mutations in the vanS(B) sensor gene that al...
متن کاملGlycopeptide resistance vanA operons in Paenibacillus strains isolated from soil.
The sequence and gene organization of the van operons in vancomycin (MIC of >256 microg/ml)- and teicoplanin (MIC of > or =32 microg/ml)-resistant Paenibacillus thiaminolyticus PT-2B1 and Paenibacillus apiarius PA-B2B isolated from soil were determined. Both operons had regulatory (vanR and vanS), resistance (vanH, vanA, and vanX), and accessory (vanY, vanZ, and vanW) genes homologous to the co...
متن کاملVariation in structure and location of VanA glycopeptide resistance elements among enterococci from a single patient.
Forty-six VanA glycopeptide-resistant enterococci (GRE) from a single patient were investigated for variation in structure and location of VanA resistance elements. Together with identification to species level and pulsed-field gel electrophoresis, these data divided the GRE into 10 groups and subgroups. Combining data in this manner appears helpful when investigating the epidemiology of GRE.
متن کاملDisruption of vanS by IS1216V in a clinical isolate of Enterococcus faecium with VanA glycopeptide resistance.
The elements that mediate VanA glycopeptide resistance in enterococci are heterogeneous. Twenty-four distinct VanA elements were identified among a collection of enterococci isolated from hospital patients and nonhuman sources in the United Kingdom (9). Despite their diversity, all these elements showed extensive homology with the prototype VanA transposon, Tn1546, from Enterococcus faecium BM4...
متن کاملGenes homologous to glycopeptide resistance vanA are widespread in soil microbial communities.
The occurrence of d-Ala : d-Lac ligase genes homologous to glycopeptide resistance vanA was studied in samples of agricultural (n=9) and garden (n=3) soil by culture-independent methods. Cloning and sequencing of nested degenerate PCR products obtained from soil DNA revealed the occurrence of d-Ala : d-Ala ligase genes unrelated to vanA. In order to enhance detection of vanA-homologous genes, a...
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ژورنال
عنوان ژورنال: FEMS Microbiology Letters
سال: 1995
ISSN: 0378-1097,1574-6968
DOI: 10.1111/j.1574-6968.1995.tb07353.x